Hideto ItoAssoc. Prof.

Hideto Ito

E-mail: ito.hideto[at]

Favorite Camera: PENTAX K-1, PENTAX K-3, PENTAX K-5IIs, PENTAX K-x
Favorite Compound: Alkyne
Favorite Catalyst: Gold
Favorite Ring Size: 7-, 8-, 9-membered rings, macrocycle

【Education & Experience】 
        Undergraduate Student
   Department of Chemistry, Graduate School of Science, Hokkaido University (Prof. Masaya Sawamura)
2007.4–2009.3:         Graduate Student (Mater Course)
   Department of Chemistry, Faculty of Science, Hokkaido University (Prof. Masaya Sawamura)  
2009.4–2012.3:         Graduate Student (Doctor Course)
   Department of Chemistry, Faculty of Science, Hokkaido University
 (Prof. Masaya Sawamura)
2009.4–2012.3:         JSPS Research Fellow (DC1)
2010.3, 2010,10–12:
Visiting Researcher
   Albert-Lüdwig Universitüt Freiberg (Prof. Barnhard Breit)
2012.4–2013.3: JSPS Research Fellow (PD)
   Department of Chemistry, Graduate School of Science, Nagoya University (Prof. Kenichiro Itami)  
2013.4–2018.8: Lecturer
Liberal Arts and Sciences, Nagoya University
2018.4–present: Associate Professor
Faculty of Science, Department of Chemistry, Nagoya University

   Department of Chemistry, Graduate School of Science, Nagoya University

2013.7–present: Collaborating Investigator
Institute of Transformative bio-Molecules (WPI-ITbM), Nagoya University
2013.10–2017.10: Collaborating Investigator
 Institute of Transformative bio-Molecules (WPI-ITbM), Nagoya University
2017.11–present: Sub-group leader
Itami Molecular Nanocarbon Project, JST-ERATO

2009: Best Disccussion Award, 21th Banyu Sapporo Symposium
2010: Otsu Conference Fellow (No.001)
2012: Ikushi Prize, JSPS
2015: Liberal Arts and Sciences Education Award, (Nagoya University)
2015: SHOWA DENKO Award in Synthetic Organic Chemistry (The Society of Synthetic Organic Chemistry, Japan)
2016: Wakashachi Incentive Research Award, Grand Prize (Aichi Prefecture)
2017: Synlett Best Paper Award 2016 (with Prof. K. Itami, Y. Segawa, Mr. Y. Yano)
2017: Verder-Scientific Award (IRMAIL Science Grant)
2018: The 32nd Chemical Society of Japan Lecture Award for Young Chemists (Chemical Society of Japan)
2018: The PCCP prize 2018, (Chemical Society of Japan & Royal Society of Chemistry)
2019: The 68th Chemical Society of Japan Award for Young Chemists (Chemical Society of Japan)
2019: Akasaki Award (Nagoya University)

【Research Area】
Organometallic Chemistry, Synthetic Organic Chemistry, Polymer Chemistry, Nanocarbon Science

【Original Papers】

[32] TBA, APEX reaction
Maciej Krzeszeski, Takehisa Maekawa, Hideto Ito, Kenichiro Itami

[31] TBA, APEX reaction
Kou P. Kawahara, Wataru Matsuoka, Hideto Ito, Kenichiro Itami

[30] An axially chiral 1,1′-biazulene and its π-extended derivative: synthesis, structures and properties
Chaolumen, Hideto Ito,* Kenichiro Itami*
Chem. Commun.
201955, 9606-9609 . DOI: 10.1039/C9CC03510A 【detail
Selected as a front cover in volume 55, issume 65.


[29] Graphene Nanoribbon Dielectric Passivation Layers for Graphene Electronics
Nobuhiko Mitoma, Yuuta Yano, Hideto Ito,* Yuhei Miyauchi,* Kenichiro Itami*
ACS Appl. Nano Mater.
201928, 4825–4831. DOI: 10.1021/acsanm.9b00767detail

[28] Living annulative π-extension polymerization for graphene nanoribbon synthesis
Yuuta Yano, Nobuhiko Mitoma,Kaho Matsushima, Feijiu Wang, Yusuke Matsui, Akira Takakura, Yuhei Miyauchi, Hideto Ito,* Kenichiro Itami*
Nature, 2019, 571, 387–392. DOI: 10.1038/s41586-019-1331-zdetail
press release (JP), press release (En)
Highlighted by Synfact 2019, 15, 0993, NHK、現代化学2019年8月号、中日新聞20190627、日刊工業新聞20190627、毎日新聞20190711、読売新聞20190630、科学新聞20190705

[27] Bay-region Selective Annotative π-Extension (APEX) of Perylene Diimides with Arynes
Takayuki Nakamuro, Kazushi Kumazawa, Hideto Ito,* Kenichiro Itami*
Synlett, 2019, 30, 423–428. DOI: 10.1055/s-0037-1611668.

[26] Discovery of Plant Growth Stimulants by C–H Arylation of 2-Azahypoxanthine
Hiroyuki Kitano, Jae-Hoon Choi, Ayaka Ueda, Hideto Ito , Shinya Hagihara, Toshiyuki Kan , Hirokazu Kawagishi , and Kenichiro Itami
Org. Lett. 2018, 20, 5684–5687. DOI: 10.1021/acs.orglett.8b02407 【detail
Highlighted in C&EN News 

[25] Annulative π-Extension of Indoles and Pyrroles with Diiodobiaryls by Pd Catalysis: Rapid Synthesis of Nitrogen-Containing Polycyclic Aromatic Compounds
Hiroyuki Kitano, Wataru Matsuoka, Hideto Ito,* Kenichiro Itami*
Chem. Sci.
2018, 9, 7556-7561. DOI: 10.1039/c8sc02802h 【detail

[24] Palladium-Catalyzed Esterification of Carboxylic Acids with Aryl Iodides
Hiroyuki Kitano, Hideto Ito,* Kenichiro Itami*
Org. Lett.
 2018, 20, 2428–2432. DOI: 10.1021/acs.orglett.8b00775 detail
Highlighted as Most read articles (7th May, 2018)

[23] C-H Arylation of Phenanthrene with Trimethylphenylsilane by Pd/o-Chloranil Catalysis: Computational Studies on the Mechanism, Regioselectivity, and Role of o-Chloranil
Mari Shibata, Hideto Ito,* Kenichiro Itami*
J. Am. Chem. Soc. 2018, 140, 2196–2205. DOI: 10.1021/jacs.7b11260detail

[22] Oxidative Homocoupling Reaction of Aryltrimethylsilanes by Pd/o-chloranil Catalysis
Mari Shibata, Hideto Ito,* Kenichiro Itami*
Chem. Lett. 2017, 46, 1701–1704. DOI: 10.1246/cl.170723.【detail

[21] Rapid Access to Nanographenes and Fused Heteroaromatics by Palladium-Catalyzed Annulative π-Extension Reaction of Unfunctionalized Aromatics with Diiodobiaryls
Wataru Matsuoka, Hideto Ito,* Kenichiro Itami*
Angew. Chem. Int. Ed. 201756, 12224–12228. DOI: 10.1002/anie.201707486 【detail
Highlighted in Organometallic Chemistry: Current Trends in Organometallic and Synthetic Chemistry

[20] Annulative π-Extension (APEX) of Heteroarenes with Dibenzosiloles and Dibenzogermoles by Palladium/o-Chloranil Catalysis
Kyohei Ozaki, Wataru Matsuoka, Hideto Ito,* Kenichiro Itami*
Org. Lett., 2017, 19, 1930–1933. DOI: 10.1021/acs.orglett.7b00684detail

[19] One-Step Annulative p-Extension of Alkynes with Dibenzosiloles Dibenzogermoles by Palladium/o-chloranil Catalysis
Kyohei Ozaki, Keiichiro Murai, Wataru Matsuoka, Katsuaki Kawasumi, Hideto Ito,* and Kenichiro Itami*
Angew. Chem. Int. Ed. 201756, 1362–1364. DOI: 10.1002/ange.201610374 detail
Selected as a Hot Paper
Highlighted in Synfacts


[18] Key Structural Elements of Unsymmetrical Cyanine Dyes for Highly Sensitive Fluorescence Turn-on DNA Probe
Kakishi Uno, Taeko Sasaki, Nagisa Sugimoto, Hideto Ito, Taishi Nishihara, Shinya Hagihara, Tetsuya Higashiyama, Narie Sasaki, Yoshikatsu Sato and Kenichiro Itami*
Chem. Asian J. 201712, 233–238. DOI: 10.1002/asia.201601430detail
Highlighted in chemistry views
Most accessed article in January 2017 (First Place)
Most accessed article in February 2017 (Third Place)
Most accessed article between March 2016 to February 2017 (22nd Place)
Most accessed article between May 2016 to April 2017 (11th place)


[17]Construction of Covalent Organic Nanotubes by Light-Induced Cross-Linking of Diacetylene-Based Helical Polymers
Kaho Maeda, Liu Hong, Taishi Nishihara, Yusuke Nakanishi, Yuhei Miyauchi, Ryo Kitaura, Naoki Ousaka, Eiji Yashima, Hideto Ito,* and Kenichiro Itami*
J. Am. Chem. Soc. 2016138, 11001–11008. DOI: 10.1021/jacs.6b05582 【detail】【press release (JP)】[press release(EN)]

TOC_revJournal of the American Chemical Society





Selected as the cover art in J. Am. Chem. Soc. 2016, vol.138, issue 38
Highlighted in JACS SPOTLIGHTS (J. Am. Chem. Soc. 2016, 138, 10717. DOI: 10.1021/jacs.6b08657)
Most Read Article Article (Total 2343 views: accessed in 5th, Sep., 2016)
Highlighted in ChemStation Spotlight Research
Highlighted in 
Academist Journal

Highlighted in News Paper: 日経産業新聞20160809中日新聞20160901科学新聞20160906




Other highlights
[Web News in Japanese]: マイナビニュースgunosyexcitedニュースJ-Net21livedoorE-start注目記事日経テクノロジーオンラインEE Times JapanYahoo ニュースBusicom Postfabcross for エンジニアSecurity Online News2channel News Navigatorはてなブックマークジョルダンニュース!ニコニコニュースgooニュースNTTドコモMapionInfoseekBiglobeニュース日経プレスリリース
[Web News in English]: Health Medicine NetworkScience ScienceDailynanowerk,  AlphaGalileoResearchSEA,  EurekAlertSpace DailyScicastsNanotechnology NowChem EuropeNano Daily
[Web News in Russian]: RAMBLER NEWS SERVICE,
[Web News in Chinese]: 权威国防科技信息门户,
[Web News in Brazil]: Inovação Tecnológica

[16] Macrocyclization by Rh-Catalyzed Cross-Cyclotrimerization of L-Shaped Diynes with Di-tert-butyl Acetylenedicarboxylate: Effect of Bent Linkers of Diynes
S. Nishigaki, Y. Miyauchi, K. Noguchi, H. Ito, K. Itami, Y. Shibata, K. Tanaka*
Eur. J. Org. Chem. 2016, 4668–4673. DOI: 10.1002/ejoc.201600909detail

[15] Helically Twisted Tetracene: Synthesis, Crystal Structure, and Photophysical Properties of Hexabenzo[a,c,fg,j,l,op]tetracene
Yuuta Yano, Hideto Ito, Yasutomo Segawa, and Kenichiro Itami
Synlett201627, 2081-2084. DOI: 10.1055/s-0035-1561455 【detail】
Selected as Synlett Best Paper Award 2016

[14]. A Theoretical Study on the Strain Energy of Carbon Nanobelts
Yasutomo Segawa, Akiko Yagi, Hideto Ito, and Kenichiro Itami
Org. Lett. 201618, 1430–1433. DOI: 10.1021/acs.orglett.6b00365 【detail】

[13]. Pyridylidene ligand facilitates gold-catalyzed oxidative C–H arylation of heterocycles
Kazuhiro Hata, Hideto Ito, Yasutomo Segawa and Kenichiro Itami
Beilstein J. Org. Chem. 201511, 2737. DOI: 10.3762/bjoc.11.295

[12].Concise Synthesis and Facile Nanotube Assembly of a Symmetrically Multi-Functionalized Cycloparaphenylene
Yuta Miyauchi, Shintaro Fujii, Kohei Johmoto, Nobuhiro Yasuda, Hideto Ito, Kenichiro Itami, Hidehiro Uekusa, Manabu Kiguchi, and Ken Tanaka
Chem. Eur. J. 2015, 21, 18900DOI: 10.1002/chem.201504185.
   selected as Hot Paper

[11]. One-shot K-region-selective Annulative π-Extension for Nanographene Synthesis and Functionalization
Kyohei Ozaki, Katsuaki Kawasumi, Mari Shibata, Hideto Ito, and Kenichiro Itami
Nature Commun. 2015, 6:6251. DOI: 10.1038/ncomms7251.【detail
   Highlighted in News Papers (Chunichi ShinbunNikkan Kogyo ShimbunZaikeishinbun)
   Highlighted in Science PortalScicastsPhys OrgAZO NANOnano werkScience DailyAsia Research NewsEurek Alert.

[10]. Thiophene-Based, Radial π-Conjugation: Synthesis, Structure, and Photophysical Properties of Cyclo-1,4-phenylene-2’,5’-thienylenes
Hideto Ito, Yukari Mitamura, Yasutomo Segawa and Kenichiro Itami
Angew. Chem. Int. Ed. 201554159-163. DOI: 10.1002/anie.201409389detail
   Selected as a inside cover picture in issue 1, 2015.
   Highlighted in Synfacts 201511,141.

[9]. One-shot Indole-to-Carbazole π-Extension by Pd-Cu-Ag Trimetallic System
Kyohei Ozaki, Hua Zhang, Hideto Ito, Aiwen Lei and Kenichiro Itami
Chem. Sci. 2013, 4, 3416–3420, DOI: 10.1039/C3SC51447A 【detail

   Most Read Articles in June and July in 2013
Selected as “HOT Chem Sci articles for June” in 2013
   Selected as Back Cover in issue 9, 2013
   Highlighted in Synfacts
   Selected as “Top 25 most-read Chemical Science articles in 2013”

[8]. Construction of Eight-Membered Carbocycles through Gold Catalysis with Acetylene-Tethered Silyl Enol Ethers
Tomohiro Iwai, Hiori Okochi, Hideto Ito and Masaya Sawamura
Angew, Chem. Int. Ed., 2013, 52, 4239–4242DOI: 10.1002/anie.201300265 

[7]. Use of a Semihollow-Shaped Triethynylphosphane Ligand for Efficient Formation of Six- and Seven-Membered Ring Ethers through Gold(I)-Catalyzed Cyclization of Hydroxy-Tethered Propargylic Esters
Hideto Ito, Ayumi Harada, Hirohisa Ohmiya, Masaya Sawamura
Adv. Synth. Catal.2013355, 647–652. DOI: 10.1002/adsc.201200949

[6]. Formation of Quaternary Carbon Centers via Highly Regioselective Hydroformylation with Catalytic Amounts of a Reversibly Bound Directing Group
Yusuke Ueki, Hideto Ito, Ippei Usui, Bernhard Breit
Chem. Eur. J.201117, 8555–8558. DOI: 10.1002/chem.201101186

[5]. Intramolecular Hydroamination of Alkynic Sulfonamides Catalyzed by Gold–Triethynylphosphine Complex: Construction of Azepine Frameworks by 7-Exodig Cyclization
Hideto Ito, Tomoya Harada, Hirohisa Ohmiya, Masaya Sawamura
Beilstein J. Org. Chem., invited paper, 20117, 951-959. DOI: 10.3762/bjoc.7.106

[4].  Construction of Methylenecycloheptane Frameworks through 7-ExoDig Cyclization of   Acetylenic Silyl Enol Ethers Catalyzed by Triethynylphosphine–Gold Complex
Hideto Ito, Hirohisa Ohmiya, Masaya Sawamura
Org. Lett. 2010, 12, 4380–4383. DOI: 10.1021/ol101860j

[3].  General and Functional Group-Tolerable Approach to Allenylsilanes by Rhodium-Catalyzed Coupling between Propargylic Carbonates and a Silylboronate
Hirohisa Ohmiya, Hideto Ito, and Masaya Sawamura
Org. Lett200911, 5618–5620. DOI: 10.1021/ol902339a

[2].  Cyclization of Non-Terminal Alkynic b-Keto Esters Catalyzed by Gold(I) Complex with a Semihollow, End-Capped Triethynylphosphine Ligand
Hideto Ito, Yusuke Makida, Atsuko Ochida, Hirohisa Ohmiya, Masaya Sawamura
Org. Lett. 200810, 5051–5054DOI: 10.1021/ol802079r

[1].  Using Triethynylphosphine Ligands Bearing Bulky End Caps to Create a Holey Catalytic Environment: Application to Gold(I)-Catalyzed Alkyne Cyclizations
Atsuko Ochida, Hideto Ito, Masaya Sawamura
J. Am. Chem. Soc2006128, 16486-16487. DOI: 10.1021/ja066800c


[5] Polycyclic Arene Synthesis by Annulative π-Extension
Hideto Ito, Yasutomo Segawa, Kei Murakami, Kenichiro Itami*
J. Am. Chem. Soc., 2019, 141, 3-10.
DOI: 10.1021/jacs.8b09232 【detail

[4] Recent advances in acetylene-based helical oligomers and polymers: Synthesis, structures, and properties

Michihisa Toya, Hideto Ito* and Kenichiro Itami*
Tetrahedron Lett (digest paper), 2018, 59, 1531–1547. DOI: 10.1016/j.tetlet.2018.03.018 【detail

[3] Annulative π-Extension (APEX): An Enabling Reaction for Rapid Access to Fused Aromatics, Heteroaromatics, and Nanographenes
Hideto Ito,* Kyohei Ozaki, and Kenichiro Itami*
Angew. Chem. Int. Ed. 2017, Early Views. DOI: 10.1002/anie.201701058.【detail

[2]. Structurally Uniform and Atomically Precise Carbon Nanostructures
Yasutomo Segawa, Hideto Ito, and Kenichiro Itami
Nature Rev. Mater. 2016, 1, 15002.(創刊号)DOI: 10.1038/natrevmats.2015.2 [detail]
highlighted in

[1]. Oxidative Cross-Coupling Reaction by Gold/Selectfluor® Catalysis
Hideto Ito
Journal of Synthetic Organic Chemistry, Japan, 2013, 76, 1075–1076. DOI: 10.5059/yukigoseikyokaishi.71.1075

[3]. 直接カップリングによる多環芳香族化合物の合成
松岡和, 伊藤英人,* 伊丹健一郎*
直接的芳香族カップリング反応の設計と応用 Development and Application of Direct Aromatic Coupling Reactions、
第12章、三浦雅博、平野康次 監修、CMC出版、2019年5月発行, ISBN: 978-4-7813-1421-1

[2]. 理系基礎化学実験、第1版、第9冊、第10冊
村田静昭、浦野扶美、吉村正宏、伊藤英人 共著、2015年2月、2016年2月、学術図書出版、ISBN: 978-4-7806-0143-5

[1]. Cross-Dehydrogenative-Coupling Reactions without Metals
Hideto Ito, Kirika Ueda, and Kenichiro Itami
From C-H to C-C Bonds : Cross-Dehydrogenative-Coupling (Eds: Chao-Jun Li, DOI: 10.1039/9781782620082), Chapter 8,
Royal Society of Chemistry, 2015, 153–196. DOI: 10.1039/9781782620082-00153.

【Research GrantsGrant Name (Grant Number), Foundation, Direct Cost
2009-2012  Grant-in-Aid for JSPS Fellows (JP09J01922), Japan Society for the Promotion of Science, 2,100,000 JPY
2012-2013  Grant-in-Aid for JSPS Fellows (JP12J30002), Japan Society for the Promotion of Science, 1,300,000JPY
2014-2017  Grant-in-Aid for Encouragement of Young Scientists (B) (JP26810057), Japan Society for the Promotion of Science, 3,100,000JPY
2014-2016  Grant for Japan-Related Research Project, Sumitomo Foundation, 1,300,000JPY
2016-2018 Grant-in-Aid for Scientific Research on Innovative Areas (JP16H00907), Science of Atomic Layer Systems, Japan Society for the Promotion of Science, 3,200,000 JPY
2016-2017 Showa Denko Award in Synthetic Organic Chemistry, Japan, 500,000 JPY
2017 Wakashachi Incentive Award Grand Prize, 300,000JPY
2018–2019 Daiko Foundation, 5,000,000 JPY
2017-2019 Grant-in-Aid for Challenging Research (Exploratory) (JP17K19155), Japan Society for the Promotion of Science, 5,000,000JPY
2018–2020 Grant- in-Aid for Scientific Research (B) (18H02019), Japan Society for the Promotion of Science, 13,700,000JPY

【Invited lectures & Presentation(click here)

Hideto Ito


Our Member

  1. Yumi Muroi
  2. Iain Stepek
  3. Shunsuke Ishida
  4. Bui Son Quy
  5. Hideyo Kinoshita
  6. Kazuma Amaike
  7. Yoko Shirotani
  8. Kotono Yamanoue
  9. Tsugunori Watanabe
  10. Motonobu Kuwayama
  11. Takayo Noguchi
  12. Yui Ueyama
  13. Rika Kato
  14. Keigo Yamada
  15. Jung Jaehyun
  16. Kosuke Watanabe
  17. Hideya Kono
  18. Kaito Maekawa
  19. Erika Kato
  20. Ryo Akagami
  21. Aki Miura
  22. Nobuhiko Mitoma
  23. Yasutomo Segawa
  24. Hiroki Sato
  25. Greco Gonzalez Miera
  26. Genki Mori
  27. Kwan Yin Cheung
  28. Mizuho Uryu
  29. Yugo Aoki


  30. Mai Nagase
  31. Kaho Matsushima
  32. Bumpei Maeda


  33. Hiroki Shudo

    もう梅雨開けたんですか!? やったー!!

  34. Chaolumen
  35. Yuanming Li
  36. Sakura Miyauchi


  37. Satoshi Matsubara

    Nice to meet you!

  38. Shusei Fujiki

    Nice to meet you!

  39. Kou Kawahara

    Nice to meet you!

  40. Rika M. Kato

    Call me Monica! I eat more!

  41. Ayaka Ueda

    Ueda rice Ayaka

  42. Ryo Okude

    Nice to meet you! No.9

  43. Akiko Yagi

    I love Ramen.

  44. Yota Sakakibara

    Fine young man

  45. Michihisa Toya

    Love Sports

  46. Yip Shu Jan (Alicia)

    1st Year PhD. Malaysian.

  47. Wataru Matsuoka

    AgO, AgO, AgO, AgO!!!

  48. Ryotaro Yamada

    final year in the Itami group!

  49. Yuuta Yano

    Graphene Yanoribbon

  50. Shuya Yamada

    3rd-year Ph.D student

  51. Takehisa Maekawa
  52. Kei Murakami

    (日本語) 特任准教授

  53. Hideto Ito

    Assoc. Prof. I Love Alkyne and Camera.

  54. Kenichiro Itami