Blog

Synthesis of Thiophene-Based TAK-779 Analogues by C–H Arylation

Anna Junker, Junichiro Yamaguchi, Kenichiro Itami, and Bernhard Wünsch

J. Org. Chem. 2013, , Accepted Manuscript. DOI: 10.1021/jo400692p

Late-Stage Diversification Strategy

A rapid synthesis of thiophene-based TAK-779 analogues is reported using a late-stage diversification strategy. At the end of the synthesis, the key building block, which was prepared in six steps from thiophene, was arylated regioselectively at the α-position directly with iodoarenes.

Related post

  1. Electro-Activated Conductivity a…
  2. Palladium-catalyzed tetraallylat…
  3. (日本語) Direct Coupling of Naphtha…
  4. Synthesis of Octaaryl Naphthalen…
  5. Synthesis, Structure, and Reacti…
  6. C-H Activation Route to Dibenzo[…
  7. Stepwise Generation of Mono-, Di…
  8. Construction of Covalent Organic…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP