Nickel-Catalyzed C-H Arylation of Azoles with Haloarenes: Scope, Mechanism, and Applications to the Synthesis of Bioactive Molecules

Takuya Yamamoto, Kei Muto, Masato Komiyama, Jerôme Canivet, Junichiro Yamaguchi, and Kenichiro Itami*

Chem. Eur. J2011, Early View

DOI: 10.1002/chem.201101091

New couples:

Novel Ni-based catalytic systems for the -H arylation of azoles with haloarenes have been developed (see scheme). Mechanistic studies as well as applications to the synthesis of biologically active com- pounds (febuxostat, tafamidis, and texaline) are also described.

Related post

  1. Making Dimethylamino a Transform…
  2. The AMOR Arabinogalactan Sugar C…
  3. Combined experimental and theore…
  4. Synthesis of Sterically Hindered…
  5. Perfluorocycloparaphenylenes
  6. Catalytic Dehydrogenative C–H Im…
  7. (日本語) test
  8. Rapid access to polycyclic thiop…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab



天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!