Blog

Synthesis of Triarylpyridines in Thiopeptide Antibiotics Using a C-H Arylation/Ring Transformation Strategy

 

 

Kazuma Amaike,Kenichiro Itami, and Junichiro Yamaguchi

Chem. Eur. J. 2016, Advanced Article DOI: 10.1002/chem.201600351

We have described a C-H arylation/ring transformation strategy for the synthesis of triarylpyridines, which form the core structure of thiopeptide antibiotics. This synthetic method readily provided 2,3,6-triarylpyridines in a regioselective manner by a two-phase approach: C-H arylation (a nickel-catalyzed decarbonylative Suzuki-Miyaura cross-coupling and decarbonylative C-H coupling for the synthesis of 2,4-diaryloxazoles) and ring transformation ([4+2] cycloaddition of 2,4-diaryloxazoles with (hetero)arylacrylic acids). To showcase these methods, we have accomplished the formal synthesis of thiopeptide antibiotics GE2270s and amythiamicins.

 

Related post

  1. CH Alkenylation of Azoles with E…
  2. Manganese-Catalyzed Intermolecul…
  3. Iridium Catalysis for C-H Bond A…
  4. Synthesis of Cycloparaphenylenes…
  5. Casein kinase 1 family regulates…
  6. Phenanthro[9,10-a]corannulene by…
  7. Strength of carbon nanotubes dep…
  8. Exploitation of an additional hy…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP