Blog

Making Dimethylamino a Transformable Directing Group by Nickel‐Catalyzed C-N Borylation

Hua Zhang, Shinya Hagihara, and Kenichiro Itami

Chem. Eur. J. 2015, 21, 16796-16800. DOI: 10.1002/chem.201503596

The dimethylamino (Me2N) group is arguably the most versatile functional group capable of highly efficient and site-selective directed aromatic functionalizations at the ortho-, meta-, and para-positions depending on reaction conditions. While the repertoire of Me2N-directed reactions is growing at a rapid pace, the lack of a general method to transform this group to other functionalities hampers its wider application in organic synthesis. Here we report nickel-catalyzed CN borylations of aryl- and benzyl-dimethylamines that permit the conversion of a huge library of largely underutilized Me2N-containing organic molecules into various functional molecules by taking advantage of the wealth of existing CB functionalization methods.

Related post

  1. Oxidative Biaryl Coupling of Thi…
  2. Synthesis and Racemization Proce…
  3. Synthesis, Structure, and Reacti…
  4. Palladium-Catalyzed C–H and C–N …
  5. Chemical hijacking of auxin sign…
  6. Synthesis of Cycloparaphenylenes…
  7. Synthesis, Structure, and Electr…
  8. A theoretical study on the strai…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab

This error message is only visible to WordPress admins
This endpoint has been retired

Error: No posts found.

Make sure this account has posts available on instagram.com.

Click here to troubleshoot

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP