Blog

β-Selective C–H Arylation of Pyrroles Leading to Concise Syntheses of Lamellarins C and I

Kirika Ueda , Kazuma Amaike , Richard M. Maceiczyk , Kenichiro Itami , and Junichiro Yamaguchi

J. Am. Chem. Soc. 2014, Just Manuscript. DOI: 10.1021/ja508449y
The first general β-selective C–H arylation of pyrroles has been developed by using a rhodium catalyst. This C–H arylation reaction, which is retrosynthetically straightforward but results in unusual regioselectivity, could result in de novo syntheses of pyrrole-derived natural products and pharmaceuticals. As such, we have successfully synthesized polycyclic marine pyrrole alkaloids, lamellarins C and I, by using this β-selective arylation of pyrroles with aryl iodides (C–H/C–I coupling) and a new double C–H/C–H coupling as key steps.

 

Related post

  1. The 1,1-Carboboration of Bis(alk…
  2. Late-Stage C-H Bond Arylation of…
  3. Initiation of carbon nanotube gr…
  4. Recent advances in acetylene-bas…
  5. Synthesis, Properties, and Packi…
  6. Dissecting plant hormone signali…
  7. [9]Cycloparaphenylene: Nickel-Me…
  8. Synthesis and Dimerization of Ch…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP