Blog

Synthesis of α-Fluoroimines by Copper-catalyzed Reaction of Diarylacetylenes and N-Fluorobenzenesulfonimide

Shu Jan Yip, Tetsushi Yoshidomi, Kei Murakami, Kenichiro Itami*

Chem. Lett. 2018, 47, 329–331. DOI: 10.1246/cl.171097

Difunctionalization of unsaturated bonds with fluorinating reagents has been regarded as an efficient route to vic- difunctional organic fluorides. Here we report a copper- catalyzed synthesis of α-fluoroimines from diarylacetylenes and N-fluorobenzenesulfonimide. Mechanistically, the reaction initiates from the generation of imidyl radical, which reacts with alkyne to give the product. The resulting α-fluoroimine can easily be transformed into other organic fluorides such as fluoroketone and fluoroamines.

Related post

  1. Gold‐Catalyzed C−H Imidation of …
  2. Adamantane-annulated arenes
  3. Synthesis of a zigzag carbon nan…
  4. Late‐Stage Functionalization of …
  5. Palladium-free synthesis of [10]…
  6. Synthesis and Properties of Meth…
  7. Synthesis of Bioactive Compounds…
  8. Synthesis of Dihydrobenzo[b]fura…

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP