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Hindered Biaryls by C–H Coupling: Bisoxazoline-Pd Catalysis Leading to Enantioselective C–H Coupling

Kazuya Yamaguchi, Junichiro Yamaguchi, Armido Studer, and Kenichiro Itami

Chem. Sci, 2012in press. DOI:10.1039/C2SC20277H

 

A new Pd-catalyzed C–H/C–B coupling of sterically hindered heteroarenes and arylboronic acids has been identified. The newly established Pd(OAc)2/bisoxazoline/TEMPO system not only enables the synthesis of sterically hindered heterobiaryls but also offers an opportunity for enantioselective biaryl coupling through C–H functionalization.

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