Recent Publication

Controlling the Circadian Clock with High Temporal Resolution through Photodosing

“Controlling the Circadian Clock with High Temporal Resolution through Photodosing”

Dusǎn Kolarski, Akiko Sugiyama, Ghislain Breton, Christin Rakers, Daisuke Ono, Albert Schulte, Florence Tama, Kenichiro Itami, Wiktor Szymanski,Tsuyoshi Hirota and Ben L. Feringa

J. Am. Chem. Soc. 2019, 141, 15784-15791.  DOI: 10.1021/jacs.9b05445

Circadian clocks, biological timekeepers that are present in almost every cell of our body, are complex systems whose disruption is connected to various diseases. Controlling cellular clock function with high temporal resolution in an inducible manner would yield an innovative approach for the circadian rhythm regulation. In the present study, we present structure-guided incorporation of photoremovable protecting groups into a circadian clock modifier, longdaysin, which inhibits casein kinase I (CKI). Using photodeprotection by UV or visible light (400 nm) as the external stimulus, we have achieved quantitative and light-inducible control over the CKI activity accompanied by an accurate regulation of circadian period in cultured human cells and mouse tissues, as well as in living zebrafish. This research paves the way for the application of photodosing in achieving precise temporal control over the biological timing and opens the door for chronophotopharmacology to deeper understand the circadian clock system.

Related post

  1. A Water-soluble Warped Nanograph…
  2. C-H Arylation of Phenanthrene wi…
  3. Synthesis and Structure of a Pro…
  4. Development and Elucidation of t…
  5. Synthesis of a carbon nanobelt
  6. Molecular Catalysis for Fulleren…
  7. Selective Synthesis of [7]- and …
  8. Synthesis and Properties of Cycl…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab

This error message is only visible to WordPress admins

Error: API requests are being delayed for this account. New posts will not be retrieved.

There may be an issue with the Instagram Access Token that you are using. Your server might also be unable to connect to Instagram at this time.

Error: No posts found.

Make sure this account has posts available on instagram.com.

Error: admin-ajax.php test was not successful. Some features may not be available.

Please visit this page to troubleshoot.

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP