Blog

Nickel-Catalyzed C−H/C−O Coupling of Azoles with Phenol Derivatives

 

Kei Muto, Junichiro Yamaguchi, and Kenichiro Itami

J. Am. Chem. Soc2011, ASAP. DOI: 10.1021/ja210249h

Highlighted in Newspapers (YomiuriChu-nichi, The Chemical Daily)

Pave new way toward ideal cross coupling

The first nickel-catalyzed C–H bond arylation of azoles with phenol derivatives have been developed. The new Ni(cod)2/dcype catalytic system is active for the coupling of various phenol derivatives such as esters, carbamates, carbonates, sulfamates, triflates, tosylates, and mesylates. By using the C–H/C–O biaryl coupling, a series of privileged 2-arylazoles including biologically active alkaloids were synthesized. Moreover, we demonstrated the utility of present reaction for functionalizing estrone and quinine.

[Nagoya University Press Release]

 

Related post

  1. Controlling the Circadian Clock …
  2. N-doped Nonalternant Aromatic Be…
  3. Toward Controlled Synthesis of C…
  4. Oxidative Biaryl Coupling of Thi…
  5. One-Step Annulative π-Extension …
  6. Pd-Catalyzed Direct C–H Bond Fun…
  7. Direct C-H Arylation of Polycycl…
  8. Regioselective Unsymmetrical Tet…

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP