Blog

Annulative π-Extension of Indoles and Pyrroles with Diiodobiaryls by Pd Catalysis: Rapid Synthesis of Nitrogen-Containing Polycyclic Aromatic Compounds

Hiroyuki Kitano, Wataru Matsuoka, Hideto Ito,* Kenichiro Itami*
Chem. Sci.
2018, Advance article. DOI: 10.1039/c8sc02802h

A palladium-catalyzed one-step annulative π-extension (APEX) reaction of indoles and pyrroles that allows rapid access to nitrogen-containing polycyclic aromatic compounds is described. In the presence of palladium pivalate and silver carbonate, diverse indoles or pyrroles coupled with diiodobiaryls in a double direct C–H arylation manner to be transformed into the corresponding π-extended compounds in a single step. The newly developed catalytic system enables the use of various pyrroles and indoles as templates with a series of diiodobiaryls to provide structurally complicated and largely π-extended nitrogen-containing polycyclic aromatic compounds that are otherwise difficult to synthesize.

Related post

  1. Synthesis of a zigzag carbon nan…
  2. Catalytic Methods for Aromatic C…
  3. Fe-Catalyzed Oxidative Coupling …
  4. Laterally π-Extended Dithia[6]he…
  5. Methylene-Bridged [6]‐, [8]‐, an…
  6. Catalytic C–H Imidation of Aroma…
  7. One-shot Indole-to-Carbazole π-E…
  8. Rapid access to polycyclic thiop…

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP