Blog

Regiodivergent Cross-Dehydrogenative Coupling of Pyridines and Benzoxazoles: Discovery of Organic Halides as Regio-Switching Oxidants

Untitled Document-1

Shuya Yamada, Kei Murakami, and Kenichiro Itami
Org. Lett. 2016, 18, 2415–2418. doi: 10.1021/acs.orglett.6b00932

Pyridine is a scaffold that is ubiquitously found in various natural products, pharmaceuticals, agrochemicals, and materials. Herein, we have developed regioselective C–H/C–H oxidative coupling of pyridine and oxazole under palladium catalysis. The regioselectivity can be controlled by the choice of oxidants. Employment of bromomesitylene afforded the C3-azolylpyridines whereas benzyl bromide worked as an efficient oxidant to give the C2-azolylpridines.
Keywords: Palladium Catalyst; Cross-dehydrogenative Oxidative Coupling; C–H Functionalization; Pyridine

Related post

  1. Palladium-Catalyzed C-H Activati…
  2. Diversity-oriented synthesis of …
  3. Catalytic Dehydrogenative C–H Im…
  4. Synthesis of partially and fully…
  5. Six-fold C–H Borylation of Hexa-…
  6. Palladium-catalyzed tetraallylat…
  7. Size-selective synthesis of [9]-…
  8. para-C−H Borylation of Benzene D…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP