Organic Chemistry Laboratory, Nagoya University

“Nickel-Catalyzed Aromatic C–H Functionalization”

Yamaguchi, J*; Muto, K.; Itami, K. Top Cure Chem, 2016,  374, 1. DOI:10.1007/s41061-016-0053-z

Catalytic C–H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon–carbon bonds and carbon–heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickel-catalyzed aromatic C–H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting-edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C–H functionalization are presented.

This article is part of the Topical Collection “Ni- and Fe-Based Cross-Coupling Reactions”, edited by Arkaitz Correa.