Blog

Controlled Alcohol–Carbonyl Interconversion by Nickel Catalysis

Takehisa Maekawa, Hiromi Sekizawa, and Kenichiro Itami Angew. Chem. Int. Ed2011in press.  DOI: 10.1002/anie.201102092

All in one pot: A general synthetic plat- form allows the interconversion of alco- hols and carbonyl compounds in a pre- dictable and controlled fashion in one pot. Under the action of a Ni catalyst, PhCl, CsF, and arylboronates, several
multistep alcohol–carbonyl interconver- sions have been achieved with good overall efficiency (see scheme). A one-pot Ni-catalyzed synthesis of flumecinol (a hepatic microsomal enzyme inducer) has also been demonstrated.

 

Related post

  1. One-shot K-region-selective annu…
  2. Making Dimethylamino a Transform…
  3. Synthesis of Triarylpyridines in…
  4. Catalytic C–H Imidation of Aroma…
  5. Flexible Reaction Pocket on Bulk…
  6. Late-Stage C-H Bond Arylation of…
  7. Thiophene-Based, Radial π-Conjug…
  8. C-H Activation Route to Dibenzo[…

Twitter@Itami Lab

Itami Lab Facebook

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP