Blog

Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair

Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Ryotaro Yamada, Masahiko Yoshimura, Takaho A Endo, Seisuke Kimura, Hua Zhang, Mika Nomoto, Yasuomi Tada, Toshinori Kinoshita, Kenichiro Itami, Shinya Hagihara,* Keiko U Torii*

Nat. Chem. Biol. 201814, 299–305. DOI: 10.1038/nchembio.2555

Auxin is a plant hormone that regulates nearly all aspects of plant growth and development through binding to its receptor TIR1. We reported development of a synthetic auxin-engineered TIR1 pair based on a bump-and-hole strategy. The synthetic auxin successfully triggered auxin signaling in plant expressing engineered TIR1 without intruding endogenous auxin system. Furthermore, by harnessing this system, we provided conclusive evidence for the role of TIR1 in auxin-mediated acid growth, which had been a controversial issue in plant science for many years. Our system enables precise control of auxin signaling, which is applicable not only to fundamental research in auxin biology, but also to efficient food production.

Press Release

Highlighted in …
Mainichi Shimbun
Crop Biotech Update
Earth.comScience Newsline Biology

Related post

  1. Excited States in Cycloparapheny…
  2. Infinitene: A Helically Twisted …
  3. π-Extended Rubrenes via Dearomat…
  4. Nickel-Catalyzed α-Arylation of …
  5. Oxidative Biaryl Coupling of Thi…
  6. Size-selective synthesis of [9]-…
  7. Synthesis and Properties of Cycl…
  8. Regiodivergent Cross-Dehydrogena…

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP