The World Premier International Research Center Initiative (WPI) is a 10-year research program, launched in 2007 by the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) in a drive to build globally visible research centers in Japan. Among the currently running 9 WPI research centers, 3 WPI “focus” centers selected in 2012, including the Institute of Transformative Bio-Molecules (ITbM) in Nagoya University, underwent an interim (mid-term) evaluation in 2016, 4 years since their launch. As a result of the evaluation, ITbM received a score of “S“, the highest possible score. ITbM is the second WPI center to receive this score, following the Kavli Institute for the Physics and Mathematics of the Universe (Kavli-IPMU), which received “S” for their interim evaluation that was conducted 5 years ago.