Blog

Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

Ryosuke Takise, Kenichiro Itami and Junichiro Yamaguchi
Org. Lett. 2016, ASAP. DOI: 10.1021/acs.orglett.6b02265

Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The fi rst nickel-catalyzed cya nation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.

Related post

  1. Exciton Recombination Dynamics i…
  2. Polycyclic Arene Synthesis by An…
  3. para-C−H Borylation of Benzene D…
  4. Branch-Selective Allylic C–H Car…
  5. N-doped Nonalternant Aromatic Be…
  6. Half-substituted fluorocyclopara…
  7. Initiation of carbon nanotube gr…
  8. Decarbonylative C–H Coupling of …

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP