1oth Yoshimasa Hirata Memorial Lecture was held on 18th Feb. 2014 at Nagoya University. This lecture is memorial for the late Prof. Yoshimasa Hirata, who researched isolation and structure determination of natural products having biological activity. In this time, Professor Martin D. Burke (University Illinois at Urbana-Champain, USA) was selected as a lecturer. And Prof. Daisuke Uemura (Kanagawa Univ.), Prof. Justin Du Bois (Stanford Univ.) and Prof. Yoshito kishi (Harverd Univ.) also joined this lecture as invited lecturer.