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Synthesis of Natural Products and Pharmaceuticals via Catalytic C–H Functionalization

Synthesis of Natural Products and Pharmaceuticals via Catalytic C–H Functionalization

Yamaguchi, J*.; Amaike, K.; Itami, K.

“Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation”、2016, Wiley-VCH [Link]

The synthesis of natural products and pharmaceuticals, particularly those containing heterocyclic frameworks, can be dramatically simplified by using catalytic C–H functionalization. C–H functionalization has gathered significant interest from the organic synthesis community because it provides a new strategy to construct carbon–carbon and carbon–heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. In this book chapter, methods in heterocycle substitution and synthesis using catalytic C–H functionalization are classified by heterocycle, with specific focus on the cutting-edge synthesis of natural products and pharmaceuticals.

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