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Recent Progress in Nickel-Catalyzed Biaryl Coupling

Junichiro Yamaguchi, Kei Muto, and Kenichiro Itami

Eur. J. Org. Chem. 2012, in press. DOI: 10.1002/ejoc.201200914


Nickel catalysis for biaryl coupling reactions has received significant attention as a less expensive and less toxic alternative to “standard” palladium catalysis. Here we describe recent developments in nickel-catalyzed biaryl coupling methodology, along with mechanistic studies and applications. In particular we focus on nickel-catalyzed coupling reactions in which “unreactive” bonds such as C–H, C–O, and C–C bonds are converted into biaryl moieties.

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