Blog

Synthesis of Multiply Arylated Pyridines

Asako, T.; Hayashi, W.; Suzuki, S.; Amaike, K.; Itami, K.; Muto, K.; Yamaguchi, J.

Tetrahedron 2017, accepted (Invited contribution). DOI: 10.1016/j.tet.2017.03.095

We have achieved a synthesis of multiply arylated pyridines by using a [4+2] cycloaddition of 2,4-diaryl-5-chloroxazoles and cinnamic acids as a key reaction. The resulting hydroxytriarylpyridines can be derivatized into triarylpyridines, tetraarylpyridines and pentaarylpyridines by sequential cross-couplings. This synthetic method allows for facile and rapid access to highly arylated pyridines with different aryl substituents.

Mr. Suzuki (left) and Ms. Hayashi (right)

Mr. Asako in Yamaguchi group in Waseda University. Congrats!

Related post

  1. Synthesis of Sterically Hindered…
  2. Annulative π-Extension (APEX): A…
  3. Annulative π-Extension of Indole…
  4. Pd-Catalyzed Direct C–H Bond Fun…
  5. Selective Introduction of Organi…
  6. Synthesis and Properties of Cycl…
  7. Late-Stage C-H Bond Arylation of…
  8. Dissecting plant hormone signali…

Twitter@Itami Lab

Itami Lab Facebook

Instagram@Itami Lab

This error message is only visible to WordPress admins
This endpoint has been retired

Error: No posts found.

Make sure this account has posts available on instagram.com.

Click here to troubleshoot

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP