Blog

Synthesis of A Heptaarylisoquinoline: Unusual Disconnection for Constructing Isoquinoline Frameworks

Synthesis of A Heptaarylisoquinoline: Unusual Disconnection for Constructing Isoquinoline Frameworks
Takashi Asako*, Shin Suzuki*, Kenichiro Itami, Kei Muto, and Junichiro Yamaguchi
(*co-first author)
Chem Lett. 2018, Advanced Publicatiion DOI 10.1246/cl.180429 Highlights Editor’s Choice

In a novel disconnection of isoquinoline ring synthesis at the C7–C8/C4a–C8a bonds, these bonds can be formed by a [4+2] cycloaddition between thiophene S,S-dioxide and alkynes. With a subsequent C–H arylation of the resulting hexaarylisoquinoline at the C3 position, the synthesis of a fully substituted isoquinoline has been achieved.

 

Related post

  1. Synthesis of a zigzag carbon nan…
  2. Thiophene-Fused π-Systems from D…
  3. The AMOR Arabinogalactan Sugar C…
  4. A Modular and Size-Selective Syn…
  5. Six-fold C–H Borylation of Hexa-…
  6. Synthesis and Racemization Proce…
  7. Oxidative Biaryl Coupling of Thi…
  8. Topologically Unique Molecular N…

最近の記事

Flickr@Itamilab

天池先輩からコーヒースープ伴夫妻からのお歳暮です!潤さん、宮村さん、ありがとうございます!!武藤さん、ビールありがとうございます!平賀大都わーいやなさん、あつしさん、ありがとうございます!!だいぶ前だけど、Stripes look #ootdHalloween lookラインを洗う時ですら格好良く。戸谷先生教育実習!imageけいしゅう、誕生日おめでとう!誕生日は英吉家!!3年生に名古屋ぼろ勝ちアピール中!!アリシア卒業おめでとう女子会!
PAGE TOP