Organic Chemistry Laboratory, Nagoya University

Name
Kei Muto
武藤 慶
(JSPS Research Fellow DC1)
(Otsu Academy Award Fellow 2013/大津会議アワードフェロー)
(2015/09/28 PhD)
2016/04/01 Promoted to Assistant Professor at Waseda University (Yamaguchi Group web site)
Chem-Station Spotlight Research

Mail Address
mutou.kei[at-mark]f.mbox.nagoya-u.ac.jp

Research Interest
Nickel-Catalyzed Coupling Reaction: C–H Functionalization, C–O Activation, Decarbonylative Coupling
Synthetic Study of Bioactive Molecules

Publication
(1) Nickel-Catalyzed C–H Arylation of Azoles with Haloarenes: Scope, Mechanism, and Applications to the Synthesis of Bioactive Molecules
Takuya Yamamoto, Kei Muto, Masato Komiyama, Jerôme Canivet, Junichiro Yamaguchi, and Kenichiro Itami
Chem. Eur. J. 2011, 17, 10113. DOI: 10.1002/chem.201101091
(2) Nickel-Catalyzed C–H/C–O coupling of Azoles with Phenol Derivatives
Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
J. Am. Chem. Soc. 2012, 134, 169. DOI: 10.1021/ja210249h
Most Read Articles in JACS during December 2011
Highlighted as Synstory in Synform Highlighted in Newspapers (Chunichi, Yomiuri, Yahoo! News, Mynavi News and so on…)
Nagoya University Press Release
(3) Decarbonylative C–H Coupling of Azoles and Aryl Esters: Unprecedented Nickel Catalysis and Application to Synthesis of Muscoride A
Kazuma Amaike, Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
J. Am. Chem. Soc. 2012, 134, 13573 DOI: 10.1021/ja306062c
(4) Recent Progress in Nickel-Catalyzed Biaryl Coupling (MicroReview)
Junichiro Yamaguchi, Kei Muto, Kenichiro Itami
Eur. J. Org. Chem. 2013,  19. DOI: 10.1002/ejoc.201200914
(5) New Cross-coupling Reactions through Nickel Catalysis (Book)
Junichiro Yamaguchi, Kazuma Amaike, Kei Muto, and Kenichiro Itami
Catalysts and Catalysis 2013, 624.
(6) Nickel-Catalyzed Direct Coupling of Heteroarenes (Review)
Junichiro Yamaguchi, Kei Muto, Kazuma Amaike, Takuya Yamamoto, and Kenichiro Itami
J. Synth. Org. Chem. Jpn. 2013, 71, 576.
(7) C–H Alkenylation of Azoles with Enols and Esters by Nickel Catalysis
Lingkui Meng, Yuko Kamada, Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
Angew. Chem., Int. Ed. 2013, 52, 10048. DOI: 10.1002/anie.201304492
(8) Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C–H/C–O Biaryl Coupling
Kei Muto, Junichiro Yamaguchi, Aiwen Lei, Kenichiro Itami
J. Am. Chem. Soc. 2013, 135, 16384. DOI: 10.1021/ja409803x
(9) Nickel-Catalyzed α-Arylation of Ketones with Phenol Derivatives
Ryosuke Takise, Kei Muto, Junichiro Yamaguchi, and Kenichiro Itami
Angew. Chem., Int. Ed. 2014, 53, 6791. DOI: 10.1002/anie.201403823
(10) Key Mechanistic Features of Ni-catalyzed C-H/C-O Biaryl Coupling of Azoles and Naphthalen-2-yl Pivalates
Huiying Xu, Kei Muto, Junichiro Yamaguchi, Cunyuan Zhao, Kenichiro Itami, and Djamaladdin G. Musaev
J. Am. Chem. Soc. 2014, 136, 14834. DOI: 10.1021/ja5071174
(11) Decarbonylative Organoboron Cross-coupling of Esters by Nickel Catalysis
Kei Muto, Junichiro Yamaguchi, Djamaladdin G. Musaev, and Kenichiro Itami
Nature Commun. 2015, 6, 7508. DOI: 10.1038/ncomms8508
Highlighted in Nature Asia.
(12) C–H Activation Generates Period Shortening Molecules Targeting Cryptochrome in the Mammalian Circadian Clock”
Tsuyoshi Oshima, Iori Yamanaka, Anupriya Kumar, Junichiro Yamaguchi, Taeko Nishiwaki-Ohkawa, Kei Muto, Rika Kawamura, Tsuyoshi Hirota, Kazuhiro Yagita, Stephan Irle, Steve A. Kay, Takashi Yoshimura, and Kenichiro Itami
Angew. Chem., Int. Ed. 2015, 54, 7193. DOI: 10.1002/anie.201502942
(13) “C–H Arylation and Alkenylation of Imidazoles by Nickel Catalysis: Solvent accelerated Imidazole C–H Activation”
Kei Muto, Taito Hatakeyama, Junichiro Yamaguchi, Kenichiro Itami
Chem. Sci. Accepted. DOI: 10.1039/C5SC02942B

Presentation
Domestic

Oral
(1) Kei Muto・Takuya Yamamoto・Masato Komiyama・Junichiro Yamaguchi・Kenichiro Itami
“Ni-Catalyzed C–H/C–X Arylation of Heteroarenes”
The 91th CSJ Annual Meeting 3C8-39 Kanagawa Univ. 2011/03/28 (Oral)
(2) Kei Muto・Junichiro Yamaguchi・Kenichiro Itami
“Ni-Catalyzed C–H Bond Direct Arylation of Heteroarenes”
The 100th Synthetic Organic Chemsitry Symposium O-37 Waseda Univ. Tokyo 2011/11/11(Oral&Poster)
(3) Kei Muto・Junichiro Yamaguchi・Kenichiro Itami
“Ni-Catalyzed C–H/C–O Coupling of Azoles with Phenol Derivatives”
The 92th CSJ Annual Meeting 4L2-37 Keio Univ. Kanagawa 2012/03/28
(4) 武藤慶・山口潤一郎・伊丹健一郎
「ニッケル触媒を用いたヘテロ芳香環の直接アリール化反応」
卓越した大学院拠点形成支援プログラム 未来有機化学を担う若手研究者交流会 京大化研 京都 2013年3月14日
(5) Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
“Direct C–H Coupling through Nickel Catalysis”
4th Otsu Conference 2013, Otsu Prince Hotel, Otsu, Japan, Oct. 21, 2013
(6) Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
“Ni-Catalyzed C–H coupling of Heteroarenes: Development, Mechanism, and Applications”
IGER Annual Meeting 2013, Nagoya University, Japan, Jan. 8, 2014
(7) Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
“Nickel-Catalyzed C–H/C–O Biaryl Coupling: Catalyst Developments and Mechanistic Studies”
The 94th CSJ Annual Meeting 2014, Nagoya University, Japan, Mar. 30, 2014
(8) Kei Muto, Junichiro Yamaguchi, and Kenichiro Itami
“Decarbonylative Suzuki–Miyaura Coupling by Nickel Catalysis”
The Chemical Society of Japan 2015, 95th Annual Meeting, Nihon University, Chiba, Japan, March 27, 2015.

Poster
(1) 武藤慶・山本拓矢・小宮山真人・山口潤一郎・伊丹健一郎
「ニッケル触媒によるアゾール類のC-Hアリール化反応」
第58回有機金属討論会 P3A-28 名古屋大学 愛知 2011年9月9日
(2) 武藤慶・山口潤一郎・伊丹健一郎
「Ni触媒を用いたヘテロ芳香環のC–H結合直接アリール化反応」
第100回有機合成シンポジウムO-37早稲田大学 国際会議場 東京 2011年11月11日 (口頭&ポスター)
(3) 武藤慶・天池一真・山口潤一郎・伊丹健一郎
「ニッケル触媒を用いたヘテロ芳香環のC–H結合直接アリール化反応」
第29回有機合成化学セミナーP-11静岡県コンベンションアーツセンター 静岡 2012年09月06日
(4) 武藤慶・天池一真・山口潤一郎・伊丹健一郎
「ニッケル触媒によるヘテロ芳香環の直接アリール化反応」
第59回有機金属化学討論会 P2A-20 大阪大学 大阪 2012年9月14日
(5) 武藤慶・天池一真・山口潤一郎・伊丹健一郎
「ニッケル触媒を用いたヘテロ芳香環C–H結合アリール化」
第46回有機金属若手の会 P 宮城蔵王ロイヤルホテル 宮城 2013年7月9日
(6) 武藤慶、山口潤一郎、伊丹健一郎
“Decarbonylative Cross-Coupling of Phenyl Esters and Arylboronic Acids with Ni Catalyst”
IGER年次報告会、名古屋大学、愛知、2014年12月

International
(1) Kei Muto, Takuya Yamamoto, Masato Komiyama, Junichiro Yamaguchi, and Kenichiro Itami
“Nickel-Catalyzed C–H/C–X Arylation of Heteroarenes”
The 4th Global COE in Chemistry Annual Synposium, Nagoya University, Jun 15, 2011. (Poster)
(2) Kei Muto, Takuya Yamamoto, Masato Komiyama, Junichiro Yamaguchi, and Kenichiro Itami
“Nickel-Catalyzed C–H Arylation of Azoles with Haloarenes”
The 10th Joint Seminar University of Münster – Nagoya University, Oct 3 – 4, 2011, Nagoya, Japan. (Poster)
(3) Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
“Direct C–H Arylation of Heteroarenes by Nickel Catalyst”
3rd International Symposium on Molecular Activation (ISMA3), 11, Sheraton Steamboat Resort, Colorado, USA Jul 27, 2013 (Oral)
(4) Kei Muto, Junichiro Yamaguchi, Aiwen Lei, Kenichiro Itami
“Ni-Catalyzed C–H/C–O Coupling of Azoles with Phenol Derivatives: Development, Mechanistic Studies, and Applications”
OMCOS17, P179, Fort Collins, Colorado, USA, Jul 29, 2013 (Poster)
(5) Kei Muto
“Ni-Catalyzed C–H/C–O Couplings: Development and Mechanistic Studies”
Core to Core/IRTG Meeting, Nagoya Univ., Nagoya, Jun 13, 2014 (Oral)
(6) Kei Muto, Junichiro Yamaguchi, and Kenichiro Itami
“Ni-Catalyzed C–H/C–O Couplings: Catalyst Development and Mechanistic Studies”
XXVI International Conference on Organometallic Chemistry (ICOMC 2014), Royton Sapporo, Hokkaido, Japan, July 17, 2014. (Poster)

Award
The 100th Synthetic Organic Chemisty Synposium:  Poster Award
The 29th Synthetic Organic Chemistry Seminar: Poster Award
The 59th Symposium on Organicmetallic Chemistry: Poster Award
2013 Distinguished Master’s Thesis Award 2012 in Dept. of Chem., Nagoya University
2013 Nagoya University Graduate School of Science Award
2013 IGER Annual Meeting: Annual Research Award
2014 The 94th CSJ Oral Student Presentation Award
2015 Nagoya University Outstanding Graduate Student Award
2016 JSPS Ikushi-Prize

Comment
The Older I am, the fatter I’m getting…
Let’s keep in touch to all of my friends ever I met.